The Ring of AirNeurotensin is an endogenous tridecapeptide found in the central nervous system. It is a neurotransmitter found in the hypothalamus, amygdala, basal ganglia, and dorsal gray of the spinal cord and it is now known that it also is produced in the intestine itself. Neurotensin plays a role in pain perception but its analgesic effects are not blocked by opioid antagonists. It also affects pituitary hormone release and gastrointestinal activity. Two possible aspects of neurotensin action in the central nervous system are involvement in the etiology of schizophrenia and its analgesic properties. Neurotensin actually is antipsychotic so that theoretically, enhancing neurotensin would prevent or treat schizophrenia. Neurotensin affects pituitary hormone regulation and a remarkable variety of gastrointestinal function. Neurotensin is a neuroleptic, not in the pharmaceutical sense of the word, but in its ability to allow cognitive dissociation. That is, neurotensin essentially increases the ability of an individual to detach from physical sensations and yet be mentally quite alert.
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